NI-488.2 for Windows 21.5 Readme

January 2022

This file contains important information about NI-488.2, including installation instructions and new features.

You can find more release information on

If you plan to use LabVIEW NXG, refer to LabVIEW NXG Support and Considerations.

Supported Operating Systems

Application Software Support

Supported Hardware

Installation Instructions

Product Security and Critical Updates

Accessing the Help

LabVIEW NXG Support and Considerations

Automating the Installation of NI Products

Using NI Software with Microsoft Windows 10

NI Software Drops Support for Phar Lap ETS Real-Time Operating System in 2022

Legal Information

Supported Operating Systems

NI-488.2 supports the following operating systems:

  • Windows 10
  • Windows Server 2016
  • Windows Server 2019
  • NI Linux® Real-Time
  • NI Real-Time Phar Lap ETS

Note  NI-488.2 no longer supports Windows Vista/XP/7/8.x, Windows Server 2003/2008/2012, or any 32-bit Windows operating system. NI-488.2 21.5 will not install or run on an unsupported OS. You cannot deploy or distribute applications that use NI-488.2 21.5 to an unsupported OS. Additionally, after installing NI-488.2 21.5, you cannot use any installers built on this computer with any version of LabVIEW, LabWindows™/CVI™, NI TestStand™, or Measurement Studio on an unsupported OS.

For more information about the changes to our OS support, visit

Application Software Support

NI-488.2 21.5 supports the following application software versions, including service packs. If you are not using NI application software, refer to Microsoft Visual Studio Support.

Application Software Versions Supported by NI-488.2
NI-VISA 21.5
LabVIEW 2018, 2019, 2020, 2021
LabVIEW Real-Time Module 2018, 2019, 2020, 2021
LabWindows™/CVI™ 2015, 2017, 2019
Measurement Studio 2019

Note:  NI I/O Trace 17.0 and later support NI-488.2 17.0. Previous versions of NI I/O Trace do not support NI-488.2 17.0 or later.

Microsoft Visual Studio Support

If you are using the NI-488.2 .NET Class Library, .NET Framework 4.0 (minimum) is required. The NI-488.2 .NET Class Library can be used with Visual C# or Visual Basic .NET in any Visual Studio version that can target .NET Framework 4.0 or .NET Framework 4.5.

To use the .NET API, you must install the .NET class libraries or the .NET wrapper in addition to the NI device driver. For information about versions of the .NET Framework and the drivers each supports, as well as the download location of the installer files, refer to National Instruments .NET Support.

Microsoft Visual Basic 6.0 Support

NI-488.2 supports 32-bit Visual Basic 6.0 application development. For more information, refer to the Language-Specific Programming Instructions topic in the NI-488.2 Help.

Unmanaged C/C++ Support

NI-488.2 supports 32-bit and 64-bit GPIB applications using Microsoft Visual C++ 2005 and later. Microsoft Visual C/C++ 6.0 and Microsoft Visual Studio .NET 2003 only support 32-bit GPIB applications. For more information, refer to the Language-Specific Programming Instructions topic in the NI-488.2 Help.

Supported Hardware

The following list details the hardware models supported in NI-488.2:

GPIB Hardware Windows 10/Server 2016/Server 2019 LabVIEW Real-Time
GPIB-ENET/1000 Yes No
NI ExpressCard-GPIB2 Yes No
NI PCIe-GPIB+ Yes Yes1
NI PCI-8232 Yes Yes
NI PXI controller with built-in GPIB Yes Yes
NI PXI-8232 Yes Yes

1Analyzer functionality is not supported.

2 This hardware is end-of-life and not recommended for new designs.

Installation Instructions

Installing NI-488.2 for LabVIEW

You can install all of your LabVIEW products—including NI-488.2—using the LabVIEW Platform media.

To request additional LabVIEW Platform media, refer to the NI website.


  • If Windows Update is enabled, the installation process might hang if Windows Update interferes with the installation of Microsoft Visual C++ 2015 Run-Time. Visit and enter the Info Code exjq43 for more information and steps to resolve this issue.
  • If you purchased this product with an NI Software Suite or NI Product Bundle, use the installation media that shipped with your purchase to install this product.

Installing NI-488.2 for LabVIEW NXG

NI automates LabVIEW NXG installation using NI Package Manager. Visit and enter the Info Code NIPMDownload to download NI Package Manager. Refer to the NI Package Manager Manual for more information about installing, removing, and upgrading NI software using NI Package Manager.

Product Security and Critical Updates

Visit to view and subscribe to receive security notifications about NI products. Visit for information about critical updates from NI.

Accessing the Help

Refer to the NI-488.2 Help, accessible by selecting National Instruments»NI-488.2»GPIB Help from the Windows menu bar.

LabVIEW NXG Support and Considerations

The following sections detail considerations for using LabVIEW NXG with NI-488.2.

LabVIEW NXG Operating Systems and System Requirements

Software support for LabVIEW NXG differs in the following ways:

  • System requirements—Only 64-bit (x64) processors are supported.
  • Operating system—Only 64-bit operating systems are supported. Refer to the Supported Operating Systems section for more information.

LabVIEW NXG Hardware Support

Support differs for the following devices in LabVIEW NXG:

  • GPIB-ENET/1000 must be manually added to your system.
    • To discover the GPIB-ENET/1000 on the local subnet, use LabVIEW NXG's Add Hardware to discover and then add it to your system.
    • To add the GPIB-ENET/1000 using its IP Address or Hostname, use LabVIEW NXG's Add hardware by address.


View context help in LabVIEW by pressing <Ctrl-H> and hovering over an object.

Search for items using the search bar in the upper right corner of the LabVIEW window. You can also view context help for the search results.

Additional documentation is available online at

LabVIEW NXG Examples

Launch LabVIEW and click the Learning tab.

LabVIEW lessons are located in the Lessons tab, and LabVIEW Examples are located in the Examples tab. Follow the instructions in the lessons and examples.

Automating the Installation of NI Products

You can automate the installation of most NI products using command-line arguments to suppress some or all of the installer user interface and dialog boxes.

If the NI product you are installing uses Microsoft .NET 4.6.2, the .NET installer may run before any NI software installs and may require a reboot before the installation of NI software begins. To avoid a .NET reboot, install .NET 4.6.2 separately before you install NI software.

For more information about automating the installation of NI products, refer to Automating an Installer in the NI Package Manager manual.

Using NI Software with Microsoft Windows 10

Microsoft Windows 10 is the latest version of the Windows operating system and features significant changes compared to previous versions. Windows 10 introduces several new capabilities and also combines features from both Windows 7 and Windows 8. For more information about NI support for Windows 10, visit

NI Software Drops Support for Phar Lap ETS Real-Time Operating System in 2022.

NI Software will drop support for Phar Lap ETS Real-Time Operating System starting in 2022. Versions of this product that ship after May 1, 2022, may not install or execute correctly on this operating system. For high-level information on the support roadmap for Phar Lap and its replacement, NI Linux Real-Time, visit To find out what hardware is supported on PXI controllers running NI Linux Real-Time, visit

Legal Information


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NI respects the intellectual property of others, and we ask our users to do the same. NI software is protected by copyright and other intellectual property laws. Where NI software may be used to reproduce software or other materials belonging to others, you may use NI software only to reproduce materials that you may reproduce in accordance with the terms of any applicable license or other legal restriction.

End-User License Agreements and Third-Party Legal Notices

You can find end-user license agreements (EULAs) and third-party legal notices in the following locations after installation:

  • Notices are located in the <National Instruments>\_Legal Information and <National Instruments> directories.
  • EULAs are located in the <National Instruments>\Shared\MDF\Legal\license directory.
  • Review <National Instruments>\_Legal Information.txt for information on including legal information in installers built with NI products.

U.S. Government Restricted Rights

If you are an agency, department, or other entity of the United States Government ("Government"), the use, duplication, reproduction, release, modification, disclosure or transfer of the technical data included in this manual is governed by the Restricted Rights provisions under Federal Acquisition Regulation 52.227-14 for civilian agencies and Defense Federal Acquisition Regulation Supplement Section 252.227-7014 and 252.227-7015 for military agencies.

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