The PXI backplane Local Bus is a daisy-chained signal path that connects each peripheral slot with its adjacent slots to the left and right. Modules exchange signals directly without passing through the system controller. Direct signal exchange between modules supports peer-to-peer communication and synchronization.

The backplane routes PXI Local Bus 6 between all slots. The backplane routes PXI Local Bus 6 between all slots. However, the left Local Bus 6 from Slot 1 and the right Local Bus 6 from Slot 18 terminate at their respective endpoints and do not continue beyond. Depending on module specifications, Local Bus signals can range from high-speed TTL signals to analog signals as high as ±42 V.

Hybrid peripheral slots connect only Local Bus 6 Left and Right. The slots do not implement other local bus lines. During system initialization, the configuration software checks local bus compatibility between adjacent modules.