The version of .NET Framework support installed by Measurement Studio depends on the version of Visual Studio used for development. The .NET Framework versions corresponding to Visual Studio Development Environments, as well as compatible Measurement Studio versions, are listed in the table below:
| Measurement Studio Version(s) | Visual Studio Version | .NET Framework Version |
| 2019 | 2015, 2017, 2019 | .NET 4.5.1 |
| 2015 | 2013 | .NET 4.5.1 |
| 2013, 2015 | 2012 | .NET 4.5 |
| 2010, 2012, 2013, 2015 | 2010 | .NET 4.0 |
| 2010, 2012, 2013 | 2008 | .NET 3.5 |
| 2010, 2012 | 2005 | .NET 2.0 |